FIBRINOLYSIS HERBAL MEDICOS

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In fibrinolysis, plasmin, an endopeptidase that is converted from plasminogen by an activator,
hydrolyzes fibrin, fibrinogen, factor V, and factor VIII to their inactive products. Hageman factor
(factor XII) converts a proactivator to the active activator. Agents such as thrombin, streptokinase,
and urokinase therefore enhance the formation of plasmin and hence have fibrinolytic properties.
Epsilon-aminocaproic acid inhibits the activator-mediated formation of plasmin and hence may
be used as an antidote to streptokinase-urokinase, or in a defibrination syndrome when bleeding
from a mucous membrane occurs.

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