ORAL ANTICOAGULANTS

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The coumarin anticoagulants include dicumarol, warfarin sodium (coumadin sodium), warfarin
potassium (Athrombin-K), acenocoumarol (Sintrom), and phenprocoumon (Liquamar).
The inanedione derivatives are phenindione (Hedulin), diphenadione (Dipaxin), and anisindione
(Miradon). The pharmacological properties of oral anticoagulants are identical qualitatively,
but their pharmacokinetic parameters and their toxicities vary. Racemic warfarin sodium is the
most widely used anticoagulant. Antithrombotic drugs are used clinically either to prevent the
formation of blood clots within the circulation (anticoagulant) or to dissolve a clot that has already
formed (thrombolytic).

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