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In fibrinolysis, plasmin,
an endopeptidase that is converted from plasminogen by an activator,
hydrolyzes fibrin, fibrinogen,
factor V, and factor VIII to their inactive products. Hageman factor
(factor XII) converts a
proactivator to the active activator. Agents such as thrombin, streptokinase,
and urokinase therefore
enhance the formation of plasmin and hence have fibrinolytic properties.
Epsilon-aminocaproic
acid inhibits
the activator-mediated formation of plasmin and hence may
be used as an antidote to
streptokinase-urokinase, or in a defibrination syndrome when bleeding
from a mucous membrane occurs.
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